Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step
نویسندگان
چکیده
منابع مشابه
The Dynamical Nature of Enzymatic Catalysis
CONSPECTUS: As is well-known, enzymes are proteins designed to accelerate specific life essential chemical reactions by many orders of magnitude. A folded protein is a highly dynamical entity, best described as a hierarchy or ensemble of interconverting conformations on all time scales from femtoseconds to minutes. We are just beginning to learn what role these dynamics play in the mechanism of...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2015
ISSN: 0003-9861
DOI: 10.1016/j.abb.2015.06.004